- Intracutaneous Reactivity
- Dermal and Mucosal Irritation (vaginal, rectal, oral)
- Ocular and Intraocular Irritation
- Closed Patch (Buehler) Dermal Irritation
- Guinea Pig Maximisation Test
- Local Lymph Node Assay (LLNA) by BrdU ELISA
Assesses the potential of device materials to cause local skin, mucosal, or ocular irritation and allergic reactions, ensuring patient comfort and biocompatibility during contact or implantation.